How to exclude products
You might not wish to have the Upsells you've made displayed on some products already part of other upsells, like global Product Bundles or collections Product Bundles, where you have not hand-picked the products.
You can easily exclude any products where you wish not to have the upsell group to apply to by using the Upsell Builder's Exclusion list.
Choose through the available upsell apps, click on that upsell app's Select Products button, choose your products from the list, and finish by clicking on the Save button. Don't forget to Save all your progress by clicking on the Save button at the top right corner as well.